Dakota Fanning
Fern Arable
Julia Roberts
Charlotte the Spider (voice)
Steve Buscemi
Templeton the Rat (voice)
John Cleese
Samuel the Sheep (voice)
Oprah Winfrey
Gussy the Goose (voice)
Cedric the Entertainer
Golly the Goose (voice)
Reba McEntire
Betsy the Cow (voice)
Kathy Bates
Bitsy the Cow (voice)
Robert Redford
Ike the Horse (voice)
Thomas Haden Church
Brooks the Crow (voice)
André 3000
Elwyn the Crow (voice)
Dominic Scott Kay
Wilbur (voice)
Sam Shepard
Narrator (voice)
Abraham Benrubi
Uncle the Pig (voice)
Kevin Anderson
Mr. Arable
Essie Davis
Mrs. Arable
Siobhan Fallon Hogan
Mrs. Zuckerman
Louis Corbett
Avery
Robyn Arthur
Teacher
Julian O'Donnell
Henry Fussy
Gary Basaraba
Homer Zuckerman
Nate Mooney
Lurvy
Nicholas Bell
Minister
Beau Bridges
Dr. Dorian
Teague Rook
Well Dressed Man
Julia Zemiro
Bystander
Denise Kirby
New Teacher
Robert Plazek
Ball Thrower
Joseph Lotesto
Young Boy
Michael Roland
Mayor
Don Bridges
Announcer
Ian Watkin
Fair Official
Joel McCrary
Sheep Group (voice)
Brian Stepanek
Sheep Group (voice)
Fred Tatasciore
Sheep Group (voice)
Bradley White
Sheep Group (voice)
Maia Kirkpatrick
Joy the Baby Spider (voice)
Jennessa Rose
Aranea the Baby Spider (voice)
Briana Hodge
Nellie the Baby Spider (voice)
Dale Azzopardi
Photographer (uncredited)
Ella Scott Lynch
Girl at Fair (uncredited)
Abraham Benrubi
Uncle The Fatter Pig(voice)
Joel McCrary
Sheep Group
Brian Stepanek
Sheep Group
Fred Tatasciore
Sheep Group