Tom Holland
Peter Parker / Spider-Man
Zendaya
MJ
Mark Ruffalo
Bruce Banner / Hulk
Jon Bernthal
Frank Castle / Punisher
Jacob Batalon
Ned Leeds
Sadie Sink
Jean Grey
Florence Pugh
Yelena Belova / Black Widow
Liza Colón-Zayas
Detective Jean DeWolff
Tramell Tillman
William 'Bill' Metzger
Marisa Tomei
May Parker
Naomi Watts
E.V. (voice)
Michael Mando
Mac Gargan / Scorpion
Keith David
Narrator of Spider Video (voice)
Marvin Jones III
Tombstone
Olivia Booth-Ford
Sara
Taryn Marie Butler
Apartment Girl
Johnny Myers
Building Manager
Billy Clements
Ramrod
Zabryna Guevara
Sheila Rivera
Nina Rose Galano
Marley
Maikol Roque
EJ
Jamel Davall Rodriguez
NYC Street Driver
Ethan Sokontwe
Scooter Kid
Tariyé Peterside
Tour Bus Guide
Phoenix Di Sebastiani
DODC Escort Guard
Vivien Keene
Female Janitor
Kurtis Lowe
DODC Box Guard
Marc Small
DODC Box Agent
David Hepple
Warehouse Worker
Jamaal Burcher
DODC Crew Chief
Lieve Carchon
Bathhouse Attendant
Mary Stillwaggon Stewart
Female DODC Guard
Luka Hays
DODC Weapons Tech
Camila López
Bodega Clerk
Robert Veng
Partygoer
Aoife Haakenson
Partygoer
Gabriel Blaikie
Partygoer
Eman Esfandi
The Boyfriend
Shing Moussa Chung
Building Tenant
Akil Young
Apartment Girl Boyfriend
Benedict Cezair-Thompson
DODC Substation Guard
Shannon Young Cho
Cindy
Niyi Akin
David
Carlos Agualusa
Businessman
Shelley Williams
Street Woman
Jud Charlton
Street Worker
John Moraitis
Balcony Guy
Beatriz Do O
Balcony Girl
Daisy Sequerra
Lucy (Bride)
Nezar Alderazi
John (Groom)
Daniel Kabanda
Cater-Waiter
Michael Magnet
Marriage Heli Pilot
Simon Schatzberger
Night Driver
Sean Carrington
DODC Tech
Anthony Nyro
DODC Prison Yard Guard
Michael Amariah
DODC Containment Guard
Fan Xiaoshuang
Snow
Elvis Carlos
Web Kid
Pat Kiernan
Pat Kiernan (uncredited)