Freddie Prinze Jr.
Fred
Sarah Michelle Gellar
Daphne
Matthew Lillard
Shaggy
Linda Cardellini
Velma
Neil Fanning
Scooby Voice (voice)
Rowan Atkinson
Mondavarious
Isla Fisher
Mary Jane
Miguel A. Núñez Jr.
Voodoo Maestro
Steven Grives
N' Goo Tuana
Charles Stan Frazier
Sugar Ray
Craig Bullock
Sugar Ray
Matthew Murphy Karges
Sugar Ray
Mark McGrath
Sugar Ray
Rodney Sheppard
Sugar Ray
Sam Greco
Zarkos
Charlie Cousins
Velma's Friend
Kristian Schmid
Brad
Nicholas Hope
Old Man Smithers
Scott Innes
Scrappy Voice (voice)
J.P. Manoux
Scrappy Rex Voice (voice)
Chris Cruickshanks
Tiny Henchman
Alex Ruiz
Reporter #1
Sheryl Benko
Reporter #2
Rio Nugara
Island Emissary
David Vallon
Bartender Dead Mike's
Troy MacKinder
Guy in the Vat
Michala Banas
Carol
Holly Brisley
Training Video Woman
Robert Díaz
Training Video Guy #1
Remi Broadway
Training Video Guy #2
Martin Broome
Melvin Doo
Simone Dumbleton
Co-Ed
Jonathan Coffey
Fitzgibbon
Michael Caffery
Coast Guard #2
Kyas Sherriff
Airport Attendant
Celeste Gosnell
Airport Family
Bradley Gosnell
Airport Family
Cayley Gosnell
Airport Family
Audrey Gosnell
Airport Family
Kurt Duval
Spooky Hotel Bartender
Janis McGavin
Co-Ed Hottie
Emily Gosnell
Autograph Seeker
Marea Lambert Barker
Autograph Seeker
Kym Jackson
Autograph Seeker
Danielle Starkey
Autograph Seeker
Andrew Bryniarski
Cavern Henchman
Craig Behenna
Henchman #1
Keith S. Bullock
Henchman #2
Jess Harnell
Creature Voices (voice)
Frank Welker
Creature Voices (voice)
Pamela Anderson
Pamela Anderson (uncredited)