John Travolta
James
Kirstie Alley
Mollie
Olympia Dukakis
Rosie
George Segal
Albert
Abe Vigoda
Grandpa
Bruce Willis
Mikey (voice)
Twink Caplan
Rona
Jason Schaller
Mikey
Jaryd Waterhouse
Mikey
Jacob Haines
Mikey
Christopher Aydon
Mikey
Joy Boushel
Melissa
Don S. Davis
Dr. Fleischer
Louis Heckerling
Lou
Brenda Crichlow
Secretary
Andrea Mann
Salesgirl
Douglas Tuck
Cab Stealer
Alex Bruhanski
Street Worker
Casey Grant
Admitting Clerk
Oscar B. Ramos
Hospital Worker
Aurelio Dinunzio
Orderly
Jeff Irvine
Admitting Doctor
Shirley Barclay
Nurse
William B. Davis
Drug Doctor
David Berner
Mr. Impatience
Jerry Wasserman
Mr. Anal
Daliah Novak
Carrie
Zena Darawalla
Lupe
Nicholas Rice
Harry
Neal Israel
Mr. Ross
Blu Mankuma
Director
William Britos
Home Orderly
Dee Jay Jackson
Burly Orderly
Ida Berner
Lady
Bea Cartmell
Lady
Eleanor Maines
Lady
Mollie Heckerling
Little Girl
Ryan McIntosh
Little Boy
Gerry Bean
Pilot Friend
Deryl Hayes
Pilot Friend
Enid Saunders
Ester
Nicole Stevens
Silly Baby
Christy Smith
Baby Megan
Sabrina Bailey
Sand Box Baby
Farah Abassi
Chatting Baby
Amber Brownmiller
Blowing Kiss Baby
Ariel Perryman
Nursery Baby
Nigel John Crowe
Nursery Baby
Michael Joseph Materi
Nursery Baby
Joan Rivers
Julie (voice) (uncredited)