Denzel Washington
Lincoln Rhyme
Angelina Jolie
Amelia Donaghy
Queen Latifah
Thelma
Michael Rooker
Captain Howard Cheney
Michael McGlone
Detective Kenny Solomon
Luis Guzmán
Eddie Ortiz
Leland Orser
Richard Thompson
John Benjamin Hickey
Dr. Barry Lehman
Bobby Cannavale
Steve, Amelia's Boyfriend
Ed O'Neill
Detective Paulie Sellitto
Richard Zeman
Lieutenant Carl Hanson
Olivia Birkelund
Lindsay Rubin
Gary Swanson
Alan Rubin
James Bulleit
Train Engineer
Frank Fontaine
Grandfather
Zena Grey
Granddaughter
Daniel Brochu
NYU Student
Desmond Campbell
Taxi Inspector
Christian Veliz
Young Boy
Mercedes Gómez
Ortiz's Mother
Mary C. Hammett
Girlfriend in Nightclub
Amanda Gay
Girl in Nightclub
Steve Adams
Gas Worker
Larry Day
Gas Worker
Burke Lawrence
Police Instructor
Terry Simpson
Cop in Apartment
Eric Davis
Cop in Apartment
Arthur Holden
Bookstore Clerk
Yahsmin Daviault
Rhyme's Sister
Keenan MacWilliam
Rhyme's Niece
David Warshofsky
Amelia's Partner
Mateo Gómez
Hot Dog Vendor
Ted Whittall
Ortiz's Assistant
Peter Michael Dillon
Homicide Detective
Jonathan Stark
Male Detective
Fulvio Cecere
Forensics Expert
Hal Sherman
Fingerprint Cop
Russell Yuen
Forensics Worker
Andy Bradshaw
Uniform Cop
Jean-Marc Bisson
Rescue Worker
Christopher Bregman
Rescue Worker
Sonya Biddle
Nurse
Phillip Noyce
Customer in Antique Bookshop (uncredited)
Charles Alonso
News Reporter (uncredited)
Michael Arthur
NYPD Officer (uncredited)
Alex Lorre
Rescue Worker (uncredited)
Todo Segalla
Cop (uncredited)
Andrew Semple
Perp (uncredited)