John Travolta
James
Kirstie Alley
Mollie
Olympia Dukakis
Rosie
Elias Koteas
Stuart
Twink Caplan
Rona
Bruce Willis
Mikey (voice)
Roseanne Barr
Julie (voice)
Damon Wayans
Eddie (voice)
Gilbert Gottfried
Joey
Mel Brooks
Mr. Toilet Man (voice)
Lorne Sussman
Mikey
Megan Milner
Julie (1 year)
Georgia Keithley
Julie (4 months)
Nikki Graham
Julie (newborn)
Danny Pringle
Eddie
Neal Israel
Mr. Ross
Lesley Ewen
Debbie
Noelle Parker
Woman Client
Douglas Warhit
Man Client
Terry David Mulligan
IRS Inspector
Paul Shaffer
Taxi Businessman
Don S. Davis
Dr. Fleischer
Morris Panych
Arrogant Businessman
Alex Bruhanski
Needle Doctor
Dorothy Fehr
Blonde
Heather Lea Gerdes
Hot Babe on Fire Escape
Robin Trapp
Cool Chick
Rick Avery
Burglar
Stephen Dimopoulos
Fire Chief
Jimmy Galeota
Punk Baby
Frank Totino
Candy Man
Coleman Lumley
Blonde Baby
Constance Barnes McCansh
Sexy Dancer
Ruby J. Munro
Businessman's Babe
Mollie Heckerling
Mikey's Dream Friend
Alicia Mizel
Slob Child
Denis Corbett
Cop (uncredited)
Yolanda Corbett
Shopper (uncredited)