Milla Jovovich
Alice
Sienna Guillory
Jill Valentine
Michelle Rodriguez
Rain
Aryana Engineer
Becky
Li Bingbing
Ada Wong
Boris Kodjoe
Luther West
Johann Urb
Leon S. Kennedy
R
Robin Kasyanov
Sergei
Kevin Durand
Barry Burton
O
Ofilio Portillo
Tony
Oded Fehr
Todd / Carlos
Colin Salmon
One
Shawn Roberts
Albert Wesker
T
Toshio Oki
Japanese Policeman
Takato Yamashita
Japanese Businessman
Mika Nakashima
J Pop Girl
Megan Charpentier
The Red Queen
A
Ava Merson-O'Brien
The Red Queen (voice)
Ray Olubowale
The Axe Men
K
Kevin Shand
The Axe Men
Hiroo Minami
Tokyo Zombie (uncredited)