Micah Abbey
Donatello (voice)
Shamon Brown Jr.
Michelangelo (voice)
Nicolas Cantu
Leonardo (voice)
Brady Noon
Raphael (voice)
Ayo Edebiri
April O'Neil (voice)
Maya Rudolph
Cynthia Utrom (voice)
John Cena
Rocksteady (voice)
Seth Rogen
Bebop (voice)
Rose Byrne
Leatherhead (voice)
Natasia Demetriou
Wingnut (voice)
Giancarlo Esposito
Baxter Stockman (voice)
Jackie Chan
Splinter (voice)
Ice Cube
Superfly (voice)
Paul Rudd
Mondo Gecko (voice)
Post Malone
Ray Fillet (voice)
Hannibal Buress
Genghis Frog (voice)
Jimmy Donaldson
Times Square Guy (voice)
Derek Wilson
Spider (voice)
Lukas Williams
Curious Goon (voice)
Michael Badalucco
Bad Bernie (voice)
Dempsey Pappion
Bald Bronson (voice)
John Capodice
Cab Driver (voice)
Andia Winslow
TV Anchor (voice)
Raechel Wong
News Anchor (voice)
David Faustino
Normal Nate (voice)
Danny Mastrogiorgio
Toupee Tom / Police Officer (voice)
Noel Gibson
Responding Police Officer / Military Advisor (voice)
Myra Owyang
Short Sharon (voice)
Kevin Eastman
Good Human (voice)
Alex Hirsch
Bossy Goon / Scumbug (voice)
Mike Rianda
Paycheck Goon / Chop Shop Boss / Ratatouille Guard (voice)
Bobby Wagner
Man Who Thought a Giant Rat was a Big Cat but was a Rat (voice)
Greg Levitan
Gecko Goon (voice)
Illya Quinteros
Helpful Construction Worker (voice)
Natalie Canizares
Sign My Baby Mom (voice)
Kyler Spears
Apologetic Goon (voice)
Jeff Rowe
Man Who Loves Being Young and Free to Go Places (voice)
Matthew Broderick
Ferris Bueller (archive footage) (uncredited)