Jim Belushi
Homer Lanza
Whoopi Goldberg
Eddie Cervi
John Waters
Robber #1
Robert Glaudini
Robber #2
James Thiel
Twin #1
Jeff Thiel
Twin #2 (as Jeffrey Thiel)
Andy Jarrell
Trucker
Anne Ramsey
Edna
Jim Mapp
Harmonica Player
Michelle Milantoni
Fat Woman in Pizza Joint
Mickey Jones
Man at Pizza Joint
Annie O'Donnell
Wife at Pizza Joint
Katherine Barrese
Waitress
Tad Horino
Mickey
Karen Black
Belle
Jack Goode Jr.
Tawdry Man
Ernestine McClendon
Esther
Pruitt Taylor Vince
Cashier
Wayne Grace
Preacher
Smitty Smith
Man Shoveling Snow
Lee Armstrong
Husband at Fruit Stand
Jan Bina
Wife at Fruit Stand
Harry Caesar
Street Person
Al Noble
Street Crazy #1
Louis B. Scott Sr.
Street Crazy #2
Sebastian Massa
Bartender
Tommy Lister Jr.
Man in Bar with Gun
Mae Mercer
Ellen
Pat Ast
Maggie Sinclair
Nick LaTour
Bar Customer
Beah Richards
Linda Cervi
Boris Aplon
Driver in Fancy Car
Angelyne
Blonde
Tony Epper
Gas Station Attendant
Vincent Schiavelli
Priest
Jimmie F. Skaggs
Jesus #1
Nancy Parsons
Maid
Tracey Walter
Tommy Dearly
Fritz Feld
Mortician
Barbara Pilavin
Mrs. Lanza
Angelo Bertolini
Mr. Lanza
Sasha Barrese
4-Year-Old Girl
Don Hanmer
Cashier #2
Ed DeFusco
Bobby French
Yelena Koreneva
Mark Winn
Homeless man (uncredited)