Will Ferrell
Sherlock Holmes
John C. Reilly
Dr. Watson
Rebecca Hall
Grace Hart
Rob Brydon
Inspector Lestrade
Kelly Macdonald
Martha Hudson
Lauren Lapkus
Millicent
Pam Ferris
Queen Victoria
Ralph Fiennes
James Moriarty
Adam Scherr
Brawn
Kieran O'Brien
Lestrade's PC Smalls
Noah Jupe
Doxy
Bella Ramsey
Flotsam
Colby Mulgrew
Hay Bag
Scarlet Grace
Pickle
Billy Jenkins
Mud Fog
Michael Culkin
Judge
Wolf Roth
Sigmund Freud
Jana Pérez
Lestrade's Wife
Nathan Osgood
Mark Twain
David Shackleton
Albert Einstein
Paul Cassidy
Charlie Chaplin
Bronson Webb
Jonathan Nightingale
Jamie-Rose Monk
Mrs. Nightingale
Jason Thorpe
Butler
Robert Cawsey
Waiter
Stanley Eldridge
Waiter
Oliver Maltman
Telegraph Operator
David Stoller
Hudson's Guard
Jack Riley
Newschild
Lilly Aspell
Newschild
Ethan Rouse
Newschild
Ellie Rose Eames
Newschild
Jamie Baughan
Titanic Ship Officer Liaison
Helen Duff
Titanic Guest
Jess Liaudin
Hangman
Wesley Kent-Hargreaves
Weird Child Companion
Daniel Fearn
Drooling Man Companion
Darren Lake
Disorientated Man Companion
Martin Bishop
Priest
Gerard Monaco
Titanic Ship Officer
Ben Lee
Houdini
Michael Buffer
Fight Fan #1
Bruce Buffer
Fight Fan #2
Russell Wilcox
Announcer
Billy Zane
Billy Zane
Hector Bateman-Harden
Young Sherlock Holmes (uncredited)
Codie-Lei Eastick
Young Watson (uncredited)
Laura Stevely
Sherlock's Mother (uncredited)
Layla Rose Boyce
Nicotine Stains / Nancy
Sadie Newman
Jane (uncredited)
Harry Baxendale
Seamus (uncredited)
Ella Bright
Bridgette (uncredited)
Kenneth Hadley
Headmaster (uncredited)
Paul Bigley
Teacher #1 (uncredited)
Sue Maund
Teacher #2 (uncredited)
Tommy Gene Surridge
Inky Hands (uncredited)
Paddy Holland
Tough Kid (uncredited)
Hugh Laurie
Mycroft Holmes (uncredited)
Steve Coogan
Gustav Klinger (uncredited)
Phil Hodges
Mr. Algernon Barkworth (uncredited)
Sara Beasley
Mrs. Frobisher (uncredited)
James Eeles
Mr. Petrucka (uncredited)
Paul T.T. Easter
John (uncredited)
Jordan Long
Herbert (uncredited)
Sonnyboy Skelton
Doxy's Dad (uncredited)
Willem Dalby
Newsie Man (uncredited)
Riley White
Jimmy (uncredited)
Lochlan White
Timmy (uncredited)
John Kinory
Instructing Solicitor (uncredited)
Benjamin Lok
Courtroom Person #3 (uncredited)
Joseph Macnab
Fitness Instructor (uncredited)
Martin Bassindale
One Man Band (uncredited)
Amelia O'Loughlin
White Star-Line Girl (uncredited)
Matthew Di Liello
Telly-Phone Assistant (uncredited)
Craig Thomas Lambert
Yeoman of the Guard (uncredited)
Jorge Leon
British Soldier (uncredited)
Martyn Mayger
Buckingham Palace Guest (uncredited)
Hugh O'Brien
Garden Party Guest (uncredited)
Deepak Anand
Nobleman (uncredited)
Shawn Dixon
Upper Class Gentleman #1 (uncredited)
Anthony Richard Rowe
Victorian Gentleman (uncredited)
Mick Slaney
Docker (uncredited)
Karl Farrer
Russian Merchant (uncredited)