Anna Faris
Cindy
Regina Hall
Brenda Meeks
Simon Rex
George
Anthony Anderson
Mahalik
Charlie Sheen
Tom
Leslie Nielsen
President Harris
Kevin Hart
CJ
Jeremy Piven
Ross Giggins
Pamela Anderson
Becca
Jenny McCarthy
Kate
Denise Richards
Annie
Elaine Klimaszewski
Elaine
Diane Klimaszewski
Diane
Drew Mikuska
Cody
Jianna Ballard
Sue
George Carlin
Architect
Queen Latifah
Aunt ShaNeequa
Marny Eng
Tabitha
Eddie Griffin
Orpheus
Camryn Manheim
Trooper Champlin
Timothy Stack
Carson Ward
Darrell Hammond
Father Muldoon
Dexter Bell
Toilet Guy
Dame Lee
Rapper #1
Doron Bell
Rapper #2
Simon Cowell
Simon Cowell
Fat Joe
Fat Joe
Ajay Naidu
Sayaman
William S. Taylor
Mr. Meeks
Patricia Idlette
Mrs. Meeks
David Edwards
Ralph
Frank C. Turner
Mr. Meek's Brother
Monica Dillon
Brenda's Grandmother
Lori Stewart
Tabitha's Mother
Jim Bremner
Guy in Chair
Phil Dornfeld
Tabitha's Voice (voice)
Edward Moss
MJ
Dee Jay Jackson
Zubie
D.L. Hughley
John Wilson
Ja Rule
Agent Thompson
Macy Gray
Macy Gray
Redman
Redman
Method Man
Method Man
Master P
Master P
Raekwon
Raekwon
RZA
RZA
U-God
U-God
Troy Yorke
Alien #1
Marco Soriano
Alien #2
Cliff Solomon
Native American #1
Byron Chief-Moon
Native American #2
Dolly Madsen
Native American #3
John Hainsworth
Tracheotomy Man
Beverley Breuer
Tracheotomy Wife
Jessie Young
Girl Scout
Deanne Henry
Tammy Fae Baker
Eric Breker
Secret Serviceman Jones
Naomi Lawson-Baird
Sweet Tabitha
Abigail Adams
Wedding Guest
Debbie Lee Carrington
Mini Tabitha (uncredited)
Tom Kenny
Alien (voice) (uncredited)
Frank Meschkuleit
Additional Performances (puppeteer)
Derek Stephen Prince
Alien (voice) (uncredited)