Melissa McCarthy
Detective Connie Edwards
Bill Barretta
Phil Philips / Junkyard / Boar (voice)
Leslie David Baker
Lt. Banning
Elizabeth Banks
Jenny
Joel McHale
Agent Campbell
Maya Rudolph
Bubbles
Dorien Davies
Sandra (voice)
Drew Massey
Goofer / Vinny (voice)
Kevin Clash
Bumblypants / Lyle (voice)
Michael McDonald
Ronovan Scargle
Cynthy Wu
Brittenie Marlowe
Mitch Silpa
Tommy
Hemky Madera
Tito
Benjamin Royer
Rick
Brekkan Spens
Dick
Ryan Tran
Phil
Fortune Feimster
Robin
Brian Palermo
Paramedic
Damon Jones
Police Station Guard John / Puppet Doctor (voice)
Ryan Gaul
Officer Milligan
Jimmy O. Yang
Officer Delancey
Dennis Keiffer
Junior
Jim Palmer
Caesar
H. Michael Croner
Jack Cook
Barry Rothbart
Fireman
Steve Mallory
Kerry
Dana Schick
Pretty Girl
Jaye Razor
Razor
Jen Sung
Sandra's Bodyguard
Bryan Cartago
Sandra's Bodyguard
Brett Wagner
Rio
Colleen Smith
Carol / Dalmatian / Cara (voice)
Ben Falcone
Donny
Victor Yerrid
Larry / Old Man Puppet (voice)
Ted Michaels
Sexist Thug / Ezra (voice)
Brian Henson
Crab
Patty Guggenheim
Roxy
Donna Kimball
Roxy / Cow / Rotten Cotton Girl (voice)
Alice Dinnean
Rotten Cotton Girl (voice)
Allan Trautman
Octopus / Puppet Doctor (voice)