Jon Voight
Alfred Kroeber
Graham Greene
Ishi
David Ogden Stiers
Dr. Saxton Pope
Jack Blessing
Tom Waterman
Anne Archer
Henriette Kroeber
Daniel Benzali
Mr. Whitney
Christianne Hauber
Miss Edna Block
Charles Martinet
Assistant Museum Director
Carl D. Parker
Sheriff Weber
Angela Paton
Mrs. Gustafson
Benne Alder
Mrs. Whatley
Marie Bain
Nurse
Loryn Barlese
Ishi's Young Sister
Gilbert Bear
Ishi's Father
Lance Brady
Reporter #4
Roy Conrad
Reporter #2
Kevin Goetz
Medical Student
Neva Hutchinson
Mrs. Berney
John Ickes
Museum Director (as John Z. Ickes)
Trudy Kinerson
Ishi's Sister
Beverly LaBeau
Ishi's Mother
Stephen Lofaro
Doctor
George Maguire
Mr. Whatley
Edward Markmann
Photographer
Wanda McCaddon
Woman with Hat
Sean David McClelland
Reporter #3
C.W. Morgan
Rudy
James O'Connell
Wester Union Operator
John Olson
Museum Goer
Stephen Pocock
Bob
Christopher Pray
Reporter #1 (as Chris Pray)
Victor Preston
Ishi's Uncle
Nick Scoggin
Alcott
Toby Stump
Young Ishi
Brian VanDerWilt
Student
Anthony Snow
Museum Patron (uncredited)
Kerry van der Griend
Bicycle Rider (uncredited)