Uma Thurman
Sissy Hankshaw
Lorraine Bracco
Delores Del Ruby
Pat Morita
The Chink
Angie Dickinson
Miss Adrian
Keanu Reeves
Julian Gitche
John Hurt
The Countess
Rain Phoenix
Bonanza Jellybean
Ed Begley Jr.
Rupert
Carol Kane
Carla
Sean Young
Marie Barth
Crispin Glover
Howard Barth
Roseanne Barr
Madame Zoe
Buck Henry
Dr. Dreyfus
Grace Zabriskie
Mrs. Hankshaw
Treva Jeffryes
Young Sissy
Ken Kesey
Sissy's Daddy
Ken Babbs
Sissy's Uncle
Allen Arnold
Lionel
Victoria Williams
Cowgirl Debbie
Heather Graham
Cowgirl Heather
Judy Robinson
Cowgirl Gloria
Betsy Roth
Cowgirl Mary
Arlene Wewa
Big Red
Heather Hershey
Cowgirl Donna
Dee Fowler
Cowgirl Kym
Udo Kier
Commercial Director
Wade Evans
Cameraman
Tom Peterson
Crewman
Alexa D'Avalon
Rubber Rose Bird Expert
Eric Hull
White House Undersecretary
Oliver Kirk
Sheriff
Joe Ivy
FBI Director
Greg McMickle
FBI Agent
Lin Shaye
Rubber Rose Maid
Chel White
Brain Surgeon
Molly Little
Salsa Singer
Scott Patrick Green
Pilgrim Man
Suzanne Solgot
Pilgrim Woman
Michael Parker
Pilgrim Driver
William S. Burroughs
Self
Sherry Alps
Cowgirl
Eliza Butterfly
Cowgirl
Boo Connolly
Cowgirl
Christie Flenniken
Cowgirl
Stacey Hyder
Cowgirl
Tina Knaggs
Cowgirl
Tom Robbins
Narrator (voice)
Roger Bowen
Naturalist (uncredited)
Edward James Olmos
Musician at Barbecue (uncredited)