Bobcat Goldthwait
Fred P. Chaney
John Candy
Don The Horse (Voice)
Dabney Coleman
Walter Sawyer
Virginia Madsen
Allison Rowe
Cindy Pickett
Victoria Peyton
Jim Metzler
Boyd Osborne
Gilbert Gottfried
The Dentist
James Hong
Boss
Burgess Meredith
Don's Dad
Jake
Dog at Party (uncredited)
Tim Kazurinsky
Leonard
Liz Torres
Bea
Harry Caesar
Gideon Cole
Mary Gross
Ms. French
Santos Morales
Carlos
Barbara Whinnery
Denise
Garry Kluger
Pomeroy
Jocko Marcellino
Marvin
Deanna Oliver
Lorraine
Allen Williams
Ted Braithwaite
Lonny Price
Frank
Chino 'Fats' Williams
Messenger
Ángel Salazar
Snake
John Lisbon Wood
Mike
Jack Whitaker
Self
Tom Wolski
Michael Murphy
Kevin Furlong
Dennis Riday
Edmund Stoiber
Head Steward
Frank Morriss
Track Announcer
Alison Moir
Party People
Donald Hotton
Minister
Jeremy Kramer
Akmar (as Jeremy S. Kramer)
Vyto Ruginis
Mr. Pandolfi
Joseph R. Sicari
Bill Freuhauf
Robert Towers
Hotel Clerk
Estelle Reiner
Mrs. Goldblatt
Mel Gold
Attendant
Peter Hobbs
Veterinarian
Barney McGeary
Agent
George D. Wallace
Orson (as George Wallace)
Karol Ballard
Female Jockey Ernestine
Don
Don
Bob Harks
Bum
Buck Henry
Fred's Dad
Conrad Hurtt
Stable Hand
Krysia Javid
Waitress