Basil Rathbone
Sherlock Holmes
Nigel Bruce
Dr. John H. Watson
Alan Mowbray
Major Duncan-Bleek
Dennis Hoey
Inspector Lestrade
Renee Godfrey
Vivian Vedder
Frederick Worlock
Prof. William Kilbane
Mary Forbes
Lady Margaret Carstairs
Skelton Knaggs
Sands - Moran's Accomplice
Billy Bevan
Conductor Taking Tickets
G
Geoffrey Steele
Roland Carstairs
J
Janet Murdoch
Mrs. Shallcross (uncredited)
Gerald Hamer
Alf Shallcross (uncredited)
Leyland Hodgson
Senior Conductor (uncredited)
Harry Cording
Mock the Undertaker (uncredited)
C
Charles Knight
Baggage Car Guard (uncredited)
B
Boyd Davis
"Inspector MacDonald" (uncredited)
B
Bobby Wissler
Mock Jr. (uncredited)
G
Gilbert Allen
Dining Car Steward (uncredited)
C. Aubrey Smith
Elderly gentleman on train station (uncredited)