Antonio Banderas
El Mariachi
Johnny Depp
CIA Agent Jeffrey Sands
Cheech Marin
Belini
Salma Hayek Pinault
Carolina
Mickey Rourke
Billy Chambers
Willem Dafoe
Armando Barillo
Eva Mendes
CIA Agent Ajedrez
Danny Trejo
Cucuy
Rubén Blades
Jorge, Retired FBI Agent
Enrique Iglesias
Lorenzo
Marco Leonardi
Fideo
Troy Robinson
Romero
Gerardo Vigil
General Marquez
Pedro Armendáriz Jr.
President of Mexico
Julio Oscar Mechoso
Nicholas, Presidential Advisor
Tito Larriva
Cab Driver
Miguel Couturier
Dr. Guevera
Tony Valdes
Chicle Boy
José Luis Avendaño
Alvaro
Rodolfo De Alexandre
Omar
Natália Torres
El Mariachi's Daughter
Steve Constancio
Right Hand
Ermahn Ospina
Qui-Que
Luz María Rojas
Pistolera
Mario Simon
Cook
Bernard Hacker
Blascoe
Cecilia Tijerina
Waitress
Carola Vázquez
Hospital Administrator
René Gatica
Chief Federale
Silvia Santoyo
Bachelorette
Juan Pablo Llaguno
Bull Fighter
Ignacio Torre
Teacher
Rojo Grau
Manny
Jorge Becerril
Taco
Víctor Carpinteiro
Left Nut
Dagoberto Gama
Que Pasa
Thomas Rosales Jr.
Bartender with Gun (uncredited)
Khristian Lupo
Soldier (uncredited)