Ron Perlman
Brother Samuel
Thomas Jane
Maj. 'Mitch' Hunter
Devon Aoki
Cpl. Valerie Duval
Sean Pertwee
Capt. Nathan Rooker
Benno Fürmann
Lt. Maximillian von Steiner
John Malkovich
Constantine
Anna Walton
Severian
Tom Wu
Cpl. Juba Kim Wu
Steve Toussaint
Capt. John McGuire
Luis Echegaray
Cpl. Jesus 'El Jesus' de Barrera
Shauna Macdonald
Adelaide
Roger Ashton-Griffiths
Science Monk
Christopher Adamson
Hodge
Jacqueline Chan
Mishima Ambassador (as Jacqui Chan)
Nicholas Ball
Plutocrat
Georgina Berriman
Grace
Georgina Bryce
Dorothy
Richard Buddle
Soldier
Tim Daniel Clark
Lead Mutant
Vyelle Croom
Bartender
Barry McCormick
Capitol Ambassador
Scott Joseph
Corporate Guard
Farhan Khan
Principal Mutant
Andrew Mackay
Science Monk's Assistant
Tatiana Lavrentieva
Refugee (uncredited)
Albert Tang
Japanese General (uncredited)
Pras Michel
Captain Michaels