Eddie Murphy
Sherman Klump / Buddy Love / Granny Klump / Mama Klump / Papa Klump / Young Papa Klump / Ernie Klump / Lance Perkins
Janet Jackson
Denise
Larry Miller
Dean Richmond
John Ales
Jason
Richard Gant
Denise's Father
Anna Maria Horsford
Denise's Mother
Melinda McGraw
Leanne Guilford
Jamal Mixon
Ernie Klump, Jr.
Gabriel Williams
Issac
Chris Elliott
Restaurant Manager
Duffy Taylor
Restaurant Trainee
Earl Boen
Dr. Knoll
Nikki Cox
Bright Student
Freda Payne
Claudine
Sylvester Jenkins
Old Willie
Wanda Sykes
Chantal
George King
Stripper
Charles Walker
Preacher
Enya Flack
Bridesmaid
Rainell Saunders
Bridesmaid
Andrea C. Robinson
Party Guest / Bridesmaid
Kym Whitley
Party Guest
Selma Stern
Mrs. Dudikoff
Julia Schultz
Receptionist
Barry W. Blaustein
Man in Bathroom
David Sheffield
Man in Bathroom
Ralph Drischell
Zeke
Myles Mason
Baby Buddy
Jeffrey Michael Freeman
Baby Buddy
Maurice Colquitt
Baby Buddy
Bill Applebaum
Boardroom Member
Harry S. Murphy
Boardroom Member
Tom Jourden
Guy in Elevator
Shawnette Heard
Dancer
Kelly Konno
Dancer
Laurie Sposit
Dancer
Nadine Ellis
Dancer
Kevin Michael Mondane
Buddy at 15
Viola Kates Stimpson
Sweet Old Lady with Dog
Naomi Morales
Buxom Student
Kente Scott
Fraternity Student
Justin Urich
Lecture Student
Sonya Eddy
Heavyset Woman
James D. Brubaker
Krusty Reporter
Richie Palmer
Cab Driver
Charles Napier
Four Star General
Steve Kehela
Scientist
Miguel A. Núñez Jr.
Scientist
Richard Saxton
Newscaster
Peter Segal
Scared Popcorn Man
William Kerr
Scared Popcorn Man
Michael Ewing
Scared Hot Dog Vendor
Nikki Segal
Scared Little Girl
Kathleen Freeman
Denise's Nosy Neighbor (uncredited)