Gwyneth Paltrow
Donna
Christina Applegate
Christine
Mark Ruffalo
Ted
Candice Bergen
Sally Weston
Joshua Malina
Randy
Kelly Preston
Sherry
Rob Lowe
Pilot Steve
Mike Myers
John
Marc Blucas
Tommy Boulay
Stacey Dash
Angela
Jon Polito
Roy Roby
Concetta Tomei
Mrs. Stewart
Robyn Peterson
Donna's Mom
Nadia Dajani
Paige
John Francis Daley
Rodney
Frederick Coffin
Mr. Stewart
Chelsey Cole
Six-Year-Old Donna
Troy Evans
Customer
David Hayward
Pete
Jorge R. Hernandez
Spanish Man
Duane King
Royalty Operations Clerk
Christina Malpero
Rita
Merrilee McCommas
June
Mary McNeal
Ted's Study Partner
Stephanie Miller
TV Interviewer
Susan Mosher
Senior Flight Attendant
Emile Ohayon
French First Class Man
Daniel Raymont
British Man
DonnaMarie Recco
Tammy
Matt Roth
Greg
Connie Sawyer
Grandma Stewart
Priscilla Inga Taylor
Janette
Jon Tenting
Donna's Co-Pilot
Jeff Yagher
Ghost Rider
Candice T. Cain
CDG Passenger (uncredited)
Jessica Capshaw
Flight Attendant (uncredited)
George Kennedy
Passenger Requesting Vodka (uncredited)
Victoria Garcia-Kelleher
Clerk #1 (uncredited)
Stephen Tobolowsky
Frank Thomas (uncredited)
Anastacia Spiegel
Runway Model at Airport (uncredited)
Valentin Siroon
Flight Attendant Trainee (uncredited)
Amy Oberer
Flight Attendant Trainee (uncredited)
Amanda Wycoff
Flight Attendant Trainee (uncredited)
Dawn-Marie Whelan
Flight Attendant Trainee (uncredited)
Greg Bronson
Fashion Photographer (uncredited)
Roark Critchlow
Tennis Pro (uncredited)
Chad Everett
Jack Weston (uncredited)
Wayne Federman
Whiskey Sour Man (uncredited)
Clarinda Ross
Diaper Woman (uncredited)
Jackie Zane
Passenger in Terminal (uncredited)