Colin Farrell
Captain Smith
Q'orianka Kilcher
Pocahontas
Christopher Plummer
Captain Newport
Christian Bale
John Rolfe
August Schellenberg
Powhatan
Wes Studi
Opechancanough
David Thewlis
Wingfield
Yorick van Wageningen
Captain Argall
Raoul Max Trujillo
Tomocomo
Michael Greyeyes
Rupwew
Kalani Queypo
Parahunt
Ben Mendelsohn
Ben
Noah Taylor
Selway
Brían F. O'Byrne
Lewes
Ben Chaplin
Robinson
Jamie Harris
Emery
Janine Duvitski
Mary
Eddie Marsan
Eddie
Joe Inscoe
Ackley
Jake Curran
James
John Savage
Savage
Thomas Clair
Patawomeck
Alex Rice
Patowomeck's Wife
Irene Bedard
Pocahontas' Mother
Ford Flannagan
Winthrop
Bev Appleton
Small
Billy Merasty
Kiskiak
Jonathan Pryce
King James
Alexandra W.B. Malick
Queen Anne
Jasper Britton
Laureate
Myrton Running Wolf
Tockwhogh
E. Danny Murphy
Bosun
Jonathan Gonitel
Thomas - 4 Yrs
Brian Merrick
Assailant
Chris Nelson
Chris
Colin Cox
Cox
Will Wallace
William Sentry
Steven Dawn
Goldsmith
Rulan Tangen
Two Moons
Jesse Borrego
Pepaschicher
Todd Wallace
Sailor
Kirk Acevedo
Sentry
Nive Nielsen
Inuit Woman
Tayla Kean
Cabin Boy 1
Thomas Steven McDonagh
Cabin Boy 2
James McDonagh
Cabin Boy 3
Gary Sundown
Messenger
Michael Goodwin
Helmsman
Sam Stevenson
Young Lady
Maria Pastel
Rosalind
Raynor Scheine
Raynor
Jeremy Radin
Jeremy
Matthew Yeung
Shaman
Gregory Labenz
Sentry 2
Miraida Rios
(voice actor)
Henry Jaderlund
Leaf Garlanded Warrior