Shirley MacLaine
Aurora Greenway
Debra Winger
Emma Greenway Horton
Jack Nicholson
Garrett Breedlove
Danny DeVito
Vernon Dahlart
Jeff Daniels
Flap Horton
John Lithgow
Sam Burns
Lisa Hart Carroll
Patsy Clark
Betty King
Rosie Dunlop
Huckleberry Fox
Teddy Horton
Troy Bishop
Tommy Horton
Shane Serwin
Younger Tommy Horton
Megan Morris
Melanie Horton
Tara Yeakey
Baby Melanie
Norman Bennett
Edward Johnson
Jennifer Josey
Young Emma
Kate Charleson
Janice
Tom Wees
Dr. Budge
Paul Menzel
Dr. Maise
F. William Parker
Doctor
Amanda Watkins
Meg
Buddy Gilbert
Dr. Ratcher
David Wohl
Phil
Shelley K. Nielsen
Nurse
Bette Croissant
Nurse
Charles Beall
Rudyard's Employer
Lelise Folse
Doris
Sharisse Baker-Bernard
Lee Anne
Judy Dickerson
Checkout Girl
Devon O'Brien
Lizbeth
Dana Vance
Victoria
Alexandra O'Karma
Jane
Nancy Mette
Woman at Party
Holly Holmberg Brooks
T.J.
Lear Levin
Jack Stern
Albert Brooks
Rudyard Greenway (voice)
Lanier Whilden
Patsy's Mother
Helen Stauffer
Flap's Secretary
Barbara Balik
Woman
Michelle Watkins
Woman
John C. Conger
Moving Man
Sandra Newkirk
Mrs. Johnson
Elaine McGown
Herself
Mary Kay Place
Doris (voice)