Morgan Freeman
Charlie
Renée Zellweger
Betty
Chris Rock
Wesley
Greg Kinnear
Dr. David Ravell
Aaron Eckhart
Del
Tia Texada
Rosa
Crispin Glover
Roy
Pruitt Taylor Vince
Ballard
Allison Janney
Lyla
Kathleen Wilhoite
Sue Ann
Elizabeth Mitchell
Chloe
Susan Barnes
Darlene
Harriet Sansom Harris
Ellen
Sung-Hi Lee
Jasmine
Laird Macintosh
Dr. Lonnie Walsh
Steven Gilborn
Blake
Jenny Gago
Mercedes
Sheila Kelley
Joyce
Matthew Cowles
Merle
Wayne Tippit
Doctor
George D. Wallace
Grandfather
Lesley Woods
Grandmother
Cynthia Martells
Chief Nurse
Alfonso Freeman
ER Doctor
Kevin Rahm
Friend #1
Steven Culp
Friend #2
Deborah May
Gloria Walsh
Max Murphy
Studio Guard
Tina Smith
Waitress
T.J. Kennedy
Cook
Irene Olga López
Rosa's Mother
Steve Franken
Administrator
Kelwin Hagen
Deputy
Josh Dotson
Parking Valet
Dona Hardy
Woman Patient
Paul Threlkeld
Grip
José Vásquez
Gang Member
Jack Jacobson
Stagehand
Elaine Corral Kendall
Anchor
Greg Bronson
Diner Patron (uncredited)
Michelle Carmen Gomez
Woman at Bar (uncredited)
Toby Linz
Sue Ann's Son (uncredited)
Hillary Straney
Woman in Hotel (uncredited)
Jenny Wade
Diner Waitress (uncredited)