Laura Linney
Dr. Karen Ross
Dylan Walsh
Dr. Peter Elliot
Ernie Hudson
Captain Monroe Kelly
Tim Curry
Herkermer Homolka
Grant Heslov
Richard
Joe Don Baker
R.B. Travis
Misty Rosas
Amy
Mary Ellen Trainor
Moira
Stuart Pankin
Boyd
Carolyn Seymour
Eleanor Romy
Romy Rosemont
Assistant
Lorene Noh
Amy
James Karen
College President / Elliot's Boss
Bill Pugin
William
Lawrence T. Wrentz
Prof. Arliss Wender
Robert Almodovar
Rudy, TraviCom Security
Kathleen Connors
Sally
Joel Weiss
TraviCom Operator
John Hawkes
Bob Driscoll
Peter Jason
Mr. Janus
Jimmy Buffett
727 Pilot
James Paradise
Transport Worker #1
William John Murphy
Transport Worker #2
Thom Barry
Samahani
Ayo Adejugbe
African Airport Guard
Kevin Grevioux
Roadblock Officer
Karara Muhoro
Roadblock Soldier
Darnell Suttles
Hospital Interrogator
Michael Chinyamurindi
Claude from Mombasa
Willie Amakye
Lead Porter
Malang
Porter
Jay Speed Forney
Porter
Shelton Mack
Porter
David Mungai
Porter
Anthony Mutune
Porter
Sylvester Mwangi
Porter
Les Robinson
Porter
Nelson Shalita
Porter
E.J. Callahan
DC-3 Pilot
Guy Toley
DC-3 Co-Pilot
Jackson Gitonga
Mizumu Tribesman
Andrew Kamuyu
Mizumu Tribesman
Fidel Bateke
Witch Doctor
Shayna Fox
Amy (voice)
Bruce Campbell
Charles Travis
Taylor Nichols
Jeffrey Weems
Adewale Akinnuoye-Agbaje
Kahega
David Anthony
Gorilla
Brian La Rosa
Gorilla
John Munro Cameron
Gorilla (as John Cameron)
John Alexander Lowe
Gorilla
Jay Caputo
Gorilla
Garon Michael
Gorilla
Peter Elliott
Gorilla
David St. Pierre
Gorilla
Eldon Jackson
Gorilla
Philip Tan
Gorilla
Nicholas Kadi
Gorilla
Christopher 'Critter' Antonucci
Gorilla
Loren Cross
Ghost Tribe Member (Uncredited)
Chris Dupre
Tribe Member (Uncredited)
Delroy Lindo
Captain Wanta (Uncredited)
Joe Pantoliano
Eddie Ventro (Uncredited)
Paul Speaks
Scientist (Uncredited)